Last update
4/8/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
USERS' SCORE
Good
Based on 7 Reviews
8.5
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
8
Magnesium enhances ibutilide for TAF
We explored how magnesium sulfate influences ibutilide's effectiveness in converting atrial flutter. This randomized, placebo-controlled study included 117 patients with typical (TAF) or atypical atrial flutter (AAF).
Results showed that magnesium significantly enhanced conversion rates in TAF patients—85% with magnesium compared to 59% with placebo. However, for AAF patients, the difference was not significant, with conversion rates at 48% versus 56%. Importantly, magnesium did not impact QT interval durations.
Results showed that magnesium significantly enhanced conversion rates in TAF patients—85% with magnesium compared to 59% with placebo. However, for AAF patients, the difference was not significant, with conversion rates at 48% versus 56%. Importantly, magnesium did not impact QT interval durations.
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5
We investigated the effects of magnesium sulphate on patients recovering from coronary artery bypass grafting. Over four days, patients received either magnesium or a placebo.
Our findings indicated that while magnesium reduced the duration of atrial flutter, it did not decrease the number of patients experiencing these arrhythmias. Additionally, patients on magnesium had fewer abnormal heartbeats. Despite promising results, magnesium treatment did not significantly alter the electrolyte levels we monitored.
Overall, magnesium appears beneficial in managing the severity of postoperative arrhythmias.
Our findings indicated that while magnesium reduced the duration of atrial flutter, it did not decrease the number of patients experiencing these arrhythmias. Additionally, patients on magnesium had fewer abnormal heartbeats. Despite promising results, magnesium treatment did not significantly alter the electrolyte levels we monitored.
Overall, magnesium appears beneficial in managing the severity of postoperative arrhythmias.
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8
Magnesium enhances ibutilide's effectiveness
We explored the combination of magnesium and ibutilide to help convert persistent atrial flutter or fibrillation in patients with rheumatic heart disease. In this study with 33 patients, raising magnesium levels significantly improved the rate of conversion to normal sinus rhythm. Astonishingly, 76% of patients successfully transitioned to sinus rhythm post-treatment. The analysis indicated that higher magnesium levels, particularly above 3.8 mg/dl, were linked to increased success rates. This suggests that magnesium could enhance ibutilide’s effectiveness in treating these heart rhythm issues.
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Most Useful Reviews
9
Atrial flutter improved
41 people found this helpful
The increased irritability and cardiac arrhythmia have vanished, sleep has improved, and the results regarding my gastrointestinal tract are excellent. At 45, I noticed irritability, restless sleep, and heart arrhythmia, especially when lying down, making it difficult to sleep and causing further annoyance. I have experienced chronic stress lately, and remedies like Valerian and Motherwort ceased to help. Conclusively, I realised a magnesium deficiency was evident in my body and began taking 1 tablet, three times daily with meals. I felt the antidepressant effect of magnesium oxide after three days! My world brightened, and I became calm. By the fifth day, the arrhythmia bothered me significantly less, which delighted me. Additionally, a slight laxative effect occurred, improving my comfort. Critics of this drug exist, but it worked wonders for me!
Read More
10
Atrial flutter eliminated
Heart arrhythmia is gone! My 16-year-old son had such severe heart arrhythmia that he could hear his heartbeat. We used Magnelis B6 without changes. On recommendation, I ordered Magnesium B6 Solgar, and a month later, the arrhythmia disappeared. Now, we continue to take it as a family and have ordered three more packages!
Read More
9
Atrial flutter resolved
Helped significantly with arrhythmia due to stress; everything improved, but I consumed the entire can.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
- All Researches
9
We evaluated how magnesium, given intravenously, impacts the effectiveness of ibutilide in converting atrial flutter or fibrillation. In a group of 229 patients, we found that those who received magnesium alongside ibutilide had a significantly higher success rate in chemical conversion—78% more likely than those who did not receive magnesium. A dose of 4 grams seemed to provide the best results. Overall, magnesium appears to enhance the efficacy of ibutilide without major complications.
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9
We explored the effectiveness of ibutilide in converting atrial flutter or fibrillation after amiodarone treatment didn’t work. In this clinical study conducted in an ICU, we monitored 26 patients with persistent arrhythmias. After giving each patient ibutilide, along with magnesium for better results, we found that 81.5% converted to normal sinus rhythm.
However, while many responded well, 11% experienced some nonsustained heart rhythm complications. This indicates ibutilide can be a reliable option when amiodarone fails, with minimal serious side effects.
However, while many responded well, 11% experienced some nonsustained heart rhythm complications. This indicates ibutilide can be a reliable option when amiodarone fails, with minimal serious side effects.
Read More
8
Magnesium enhances ibutilide's effectiveness
We explored the combination of magnesium and ibutilide to help convert persistent atrial flutter or fibrillation in patients with rheumatic heart disease. In this study with 33 patients, raising magnesium levels significantly improved the rate of conversion to normal sinus rhythm. Astonishingly, 76% of patients successfully transitioned to sinus rhythm post-treatment. The analysis indicated that higher magnesium levels, particularly above 3.8 mg/dl, were linked to increased success rates. This suggests that magnesium could enhance ibutilide’s effectiveness in treating these heart rhythm issues.
Read More
8
We examined the role of high doses of magnesium in enhancing the safety and effectiveness of ibutilide for converting atrial flutter to normal sinus rhythm.
A study involving 476 patients revealed that those who received magnesium alongside ibutilide had a higher conversion rate to normal rhythm and experienced significantly fewer ventricular complications.
With only 1.2% of magnesium patients developing serious issues compared to 7.4% in those who only got ibutilide, it’s clear that magnesium offers protective benefits.
A study involving 476 patients revealed that those who received magnesium alongside ibutilide had a higher conversion rate to normal rhythm and experienced significantly fewer ventricular complications.
With only 1.2% of magnesium patients developing serious issues compared to 7.4% in those who only got ibutilide, it’s clear that magnesium offers protective benefits.
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8
Magnesium enhances dofetilide effectiveness
We investigated whether intravenous magnesium enhances the effectiveness of dofetilide in converting atrial flutter (AFL) or fibrillation (AF) to normal sinus rhythm. The study included 160 patients who received dofetilide, with some also getting magnesium.
While the overall success rate of conversion was 41.9%, those treated with magnesium had a 107% increase in chances of successful cardioversion compared to those who did not receive it. This highlights that magnesium could indeed be beneficial when used alongside dofetilide in managing AF or AFL.
While the overall success rate of conversion was 41.9%, those treated with magnesium had a 107% increase in chances of successful cardioversion compared to those who did not receive it. This highlights that magnesium could indeed be beneficial when used alongside dofetilide in managing AF or AFL.
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User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Atrial flutter improved
41 people found this helpful
The increased irritability and cardiac arrhythmia have vanished, sleep has improved, and the results regarding my gastrointestinal tract are excellent. At 45, I noticed irritability, restless sleep, and heart arrhythmia, especially when lying down, making it difficult to sleep and causing further annoyance. I have experienced chronic stress lately, and remedies like Valerian and Motherwort ceased to help. Conclusively, I realised a magnesium deficiency was evident in my body and began taking 1 tablet, three times daily with meals. I felt the antidepressant effect of magnesium oxide after three days! My world brightened, and I became calm. By the fifth day, the arrhythmia bothered me significantly less, which delighted me. Additionally, a slight laxative effect occurred, improving my comfort. Critics of this drug exist, but it worked wonders for me!
Read More
10
Atrial flutter eliminated
Heart arrhythmia is gone! My 16-year-old son had such severe heart arrhythmia that he could hear his heartbeat. We used Magnelis B6 without changes. On recommendation, I ordered Magnesium B6 Solgar, and a month later, the arrhythmia disappeared. Now, we continue to take it as a family and have ordered three more packages!
Read More
9
Atrial flutter resolved
Helped significantly with arrhythmia due to stress; everything improved, but I consumed the entire can.
Read More
7.5
Atrial flutter reduced
Excellent magnesium with vitamin B6. I'm still taking it, but I have already begun sleeping better, and the frequency of arrhythmia and apnea attacks has decreased.
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7.5
Atrial flutter addressed
Good, it's beneficial for arrhythmia. I have been taking three tablets daily for about two years, and it seems helpful.
Read More
Frequently Asked Questions
9
Atrial flutter improved
41 people found this helpful
The increased irritability and cardiac arrhythmia have vanished, sleep has improved, and the results regarding my gastrointestinal tract are excellent. At 45, I noticed irritability, restless sleep, and heart arrhythmia, especially when lying down, making it difficult to sleep and causing further annoyance. I have experienced chronic stress lately, and remedies like Valerian and Motherwort ceased to help. Conclusively, I realised a magnesium deficiency was evident in my body and began taking 1 tablet, three times daily with meals. I felt the antidepressant effect of magnesium oxide after three days! My world brightened, and I became calm. By the fifth day, the arrhythmia bothered me significantly less, which delighted me. Additionally, a slight laxative effect occurred, improving my comfort. Critics of this drug exist, but it worked wonders for me!
10
Atrial flutter eliminated
Heart arrhythmia is gone! My 16-year-old son had such severe heart arrhythmia that he could hear his heartbeat. We used Magnelis B6 without changes. On recommendation, I ordered Magnesium B6 Solgar, and a month later, the arrhythmia disappeared. Now, we continue to take it as a family and have ordered three more packages!
9
Atrial flutter resolved
Helped significantly with arrhythmia due to stress; everything improved, but I consumed the entire can.
7.5
Atrial flutter alleviated
An excellent drug; while taking it alongside general therapy, my mother's arrhythmia became less bothersome. Perhaps a coincidence, as the other magnesium (in a good form, chelated) did not yield such results. It's advisable to have vitamins recommended or prescribed by a doctor.
7.5
Atrial flutter addressed
Good, it's beneficial for arrhythmia. I have been taking three tablets daily for about two years, and it seems helpful.
References
- Kukendrarajah K, Ahmad M, Carrington M, Ioannou A, Taylor J, et al. External electrical and pharmacological cardioversion for atrial fibrillation, atrial flutter or atrial tachycardias: a network meta-analysis. Cochrane Database Syst Rev. 2024;6:CD013255. 10.1002/14651858.CD013255.pub2
- Malkoc A, Phan A, Falatoonzadeh P, Mac O, Sherman W, et al. Gender Differences With Ibutilide Effectiveness and Safety in Cardioversion of Atrial Fibrillation. J Surg Res. 2024;296:10. 10.1016/j.jss.2023.12.002
- Malviya A, Kapoor M, Sivam RKN, Khan SA, Pandey R, et al. Ibutilide with magnesium for conversion of atrial fibrillation or flutter in rheumatic heart disease patients: Ibutilide with magnesium for chemical cardioversion of atrial fibrillation or flutter. Indian Heart J. 2020;72:283. 10.1016/j.ihj.2020.07.008
- Wang A. Efficacy of class III antiarrhythmics and magnesium combination therapy for atrial fibrillation. Pharm Pract (Granada). 2012;10:65. PubMed
- Patsilinakos S, Christou A, Kafkas N, Nikolaou N, Antonatos D, et al. Effect of high doses of magnesium on converting ibutilide to a safe and more effective agent. Am J Cardiol. 2010;106:673. 10.1016/j.amjcard.2010.04.020
- Coleman CI, Sood N, Chawla D, Talati R, Ghatak A, et al. Intravenous magnesium sulfate enhances the ability of dofetilide to successfully cardiovert atrial fibrillation or flutter: results of the Dofetilide and Intravenous Magnesium Evaluation. Europace. 2009;11:892. 10.1093/europace/eup084
- Steinwender C, Hönig S, Kypta A, Kammler J, Schmitt B, et al. Pre-injection of magnesium sulfate enhances the efficacy of ibutilide for the conversion of typical but not of atypical persistent atrial flutter. Int J Cardiol. 2010;141:260. 10.1016/j.ijcard.2008.12.012
- Tercius AJ, Kluger J, Coleman CI, White CM. Intravenous magnesium sulfate enhances the ability of intravenous ibutilide to successfully convert atrial fibrillation or flutter. Pacing Clin Electrophysiol. 2007;30:1331. PubMed
- Bregvadze IN, Maĭkov EB, Bil'dinov OA, Kratskina TL, Klimenko IuL, et al. [The efficacy and safety of nibentan for pharmacological cardioversion in patients with persistent atrial fibrillation and flutter: the role of dose limitation and magnesium sulfate administration]. Kardiologiia. 2007;47:48. PubMed
- Sedrakyan A, Treasure T, Browne J, Krumholz H, Sharpin C, et al. Pharmacologic prophylaxis for postoperative atrial tachyarrhythmia in general thoracic surgery: evidence from randomized clinical trials. J Thorac Cardiovasc Surg. 2005;129:997. PubMed
- Kalus JS, Spencer AP, Tsikouris JP, Chung JO, Kenyon KW, et al. Impact of prophylactic i.v. magnesium on the efficacy of ibutilide for conversion of atrial fibrillation or flutter. Am J Health Syst Pharm. 2003;60:2308. PubMed
- Caron MF, Kluger J, Tsikouris JP, Ritvo A, Kalus JS, et al. Effects of intravenous magnesium sulfate on the QT interval in patients receiving ibutilide. Pharmacotherapy. 2003;23:296. PubMed
- Hennersdorf MG, Perings SM, Zühlke C, Heidland UE, Perings C, et al. Conversion of recent-onset atrial fibrillation or flutter with ibutilide after amiodarone has failed. Intensive Care Med. 2002;28:925. PubMed
- Jensen BM, Alstrup P, Klitgård NA. Magnesium substitution and postoperative arrhythmias in patients undergoing coronary artery bypass grafting. Scand Cardiovasc J. 1997;31:265. PubMed
- Joshi PP, Deshmukh PK, Salkar RG. Efficacy of intravenous magnesium sulphate in supraventricular tachyarrhythmias. J Assoc Physicians India. 1995;43:529. PubMed
- Casthely PA, Yoganathan T, Komer C, Kelly M. Magnesium and arrhythmias after coronary artery bypass surgery. J Cardiothorac Vasc Anesth. 1994;8:188. PubMed
Data last updated:
